ZIOPHARM Oncology commences Phase I/II study of Zybulin for metastatic breast cancer

January 02, 2016

Clifford A. Hudis, M.D., Chief of the Breast Cancer Medicine Service at Memorial Sloan-Kettering Cancer Center, noted, "The development of an additional new therapy for breast cancer that is effective but with fewer of the more significant side effects associated with many commonly used therapies would be an important step in the treatment of this disease. We look forward to testing this novel agent and dosing schedule in patients."

The study will implement a mathematically modeled drug administration schedule that was developed in preclinical studies by Larry Norton, M.D. as a consultant to ZIOPHARM Oncology, Inc. The model capitalizes on the convenience and scheduling flexibility of oral administration to maximize anticancer activity, minimize potential toxicity and resistance, and exploit the drug's mechanisms of action on both cancer cell division and cell movement. Findings from the preclinical studies were presented at the 2009 American Society of Clinical Oncology annual meeting.

Memorial Sloan-Kettering's Breast Cancer Medicine team, under the direction of Dr. Hudis, has successfully translated preclinical work into meaningful clinical treatment in past studies, and will lead this Phase I/II trial.

Source ZIOPHARM Oncology, Inc.