VARI researchers find ways to reverse resistance to sunitinib: Patients with ccRCC show positive response
November 05, 2015
"The development of ccRCC resistance to sunitinib treatment is of major clinical concern," said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., whose laboratory published its findings in this month's issue of Cancer Research. "It is now of critical importance to validate these findings in the clinical setting."
Another study from Teh's laboratory also published in Cancer Research this month looked into exactly how sunitinib works. The study found that the treatment does not target tumor cells, but rather the tumor's blood supply.
"Understanding how sunitinib works should have important implications for the improved treatment of ccRCC and perhaps other cancers as well," said VARI Postdoctoral Fellow Dan Huang, Ph.D., lead author of both studies.
"These insights will help build upon recent advances to extend clinical benefits to more patients with metastatic kidney cancer," said Dr. Rini.
Source: Van Andel Research Institute