Neoprobe completes Phase 3 Lymphoseek clinical trial on breast cancer patients

September 07, 2015

"Xanthohumol prevented the receptor from translocating to the cell nucleus, thus inhibiting its potential to stimulate the secretion of PSA and other hormone-dependent effects," she said.

Molecular modeling results showed that xanthohumol directly binds to the androgen receptor structure.

The researchers suggest that this compound may have beneficial effects in animals ?? when they measured the anti-androgenic potential of xanthohumol in a rat model, they found that although xanthohumol was not able to prevent an increase in prostate weight after testosterone treatment, it could reduce testosterone-increased seminal vesicle weight.

"Although the prostate weights were not changed, xanthohumol still reduced the effects of hormone signaling, such as gene expression, measured in the prostate tissue," said Gerhauser.

Source: American Association for Cancer Research