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APO-VERAP (CALAN) INDICATIONS

Apo-verap is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically atrial fibrillation and atrial flutter. Apo-verap is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

APO-VERAP (CALAN) INSTRUCTIONS

Use Apo-verap as directed by your doctor.

  • Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
  • Your doctor may occasionally change your dose to make sure you get the best results.
  • Do not crush, chew, break, or open Apo-verap. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.
  • Do not stop taking this medication without first talking to your doctor. If you stop taking Apo-verap suddenly, your condition may become worse.
  • If you miss a dose of Apo-verap, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Apo-verap.

APO-VERAP (CALAN) STORAGE

Store Apo-verap at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Apo-verap out of the reach of children and away from pets.

APO-VERAP (CALAN) MORE INFO:

Active Ingredient: Verapamil hydrochloride.

Do NOT use Apo-verap if:

  • you are allergic to any ingredient in Apo-verap
  • you have certain heart problems (eg, left ventricular dysfunction, sick sinus syndrome, second- or third-degree heart block and do not have a pacemaker), very low blood pressure, or moderate to severe congestive heart failure (CHF)
  • you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White (WPW) syndrome or Lown-Ganong-Levine (LGL) syndrome
  • you have shock due to serious heart problems
  • you are taking dofetilide, or you have taken disopyramide within the past 48 hours.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Apo-verap. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart failure or a recent heart attack with lung congestion, low blood pressure, or heart problems (eg, a very slow heart rate, heart block, heart valve disease)
  • if you have kidney or liver problems, muscular dystrophy, or a neuromuscular disease
  • if you are taking another blood pressure medicine or you are being treated for cancer.

Some medicines may interact with Apo-verap. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), clonidine, disopyramide, ketolides (eg, telithromycin), macrolides (eg, erythromycin), or ritonavir because they may increase the risk of Apo-verap's side effects
  • Phenobarbital, rifampin, or St. John's wort because they may decrease Apo-verap's effectiveness
  • Aldosterone blockers (eg, eplerenone), aspirin, carbamazepine, colchicine, cyclosporine, digoxin, dofetilide, doxorubicin, dronedarone, eletriptan, erythromycin, everolimus, flecainide, HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), lithium, narcotic pain relievers (eg, fentanyl), paclitaxel, quinazolines (eg, terazosin), quinidine, ranolazine, theophyllines, or tolvaptan because the risk of their side effects may be increased by Apo-verap.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Apo-verap may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Apo-verap may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Apo-verap with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Apo-verap; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Apo-verap may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Tell your doctor or dentist that you take Apo-verap before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver function, kidney function, complete blood cell counts, electrocardiogram (ECG), and blood pressure, may be performed while you use Apo-verap. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Apo-verap with caution in the elderly; they may be more sensitive to its effects.
  • Apo-verap should not be used in childen; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Apo-verap while you are pregnant. Apo-verap is found in breast milk. If you are or will be breast-feeding while you use Apo-verap, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effectspersist or become bothersome:

Dizziness; fatigue; headache; lightheadedness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; lightheadedness, especially when standing; severe dizziness; shortness of breath; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, severe or persistent stomach pain, fever, general feeling of being unwell); unusually fast, slow, or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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